Saikogenin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Saikogenin A 是一种二肽基肽酶 4 抑制剂。

Saikogenin A is a dipeptidyl peptidase-4 inhibitor.

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.

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Metabolic Enzyme/Protease

DPP

DPP-4

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5092-09-1

472.7

C30H48O4

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (52.89 mM)

CC(C)(CC[C@]12CO)CC1=C1C=C[C@H]([C@@](C)(CC3)[C@@H](CC4)[C@](C)(CO)[C@H]3O)[C@]4(C)[C@]1(C)C[C@@H]2O

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(-20℃)

With Ice Pack

≥ 2 years