AN2718

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AN2718 是一种苯并氧杂硼化合物，在体外表现出广泛的抗真菌功效。

AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. This enzyme plays an essential role in fungal protein synthesis by attaching the leucine amino acid to transfer RNA, or tRNA. AN2718, an investigational topical anti-fungal product candidate for the potential treatment of skin and nail infections. At various concentrations, AN2718 gel showed low irritation potential, leading investigators to conclude that application site reactions in future efficacy trials would be unlikely.(In Vitro):AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.

AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.

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AN2718 | AN-2718 | AN 2718

Metabolic Enzyme/Protease

DPP

leucyl-tRN/A synthetase

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174672-06-1

168.4

C7H6BClO2

>98% (HPLC)

In Vitro:?DMSO : ≥ 50 mg/mL (296.93 mM)

c12c(ccc(c1)Cl)B(OC2)O

5-chlorobenzo[c][1,2]oxaborol-1(3H)-ol

(-20℃)

With Ice Pack

≥ 2 years