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VTP50469
CAS No. 2169916-18-9
VTP50469 ( —— )
产品货号. M23981 CAS No. 2169916-18-9
VTP50469 是一种高选择性、口服活性的 Menin-MLL 相互作用抑制剂 (Ki: 104 pM)，具有有效的抗白血病活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1691 | 有现货 |
|
| 5MG | ￥2679 | 有现货 |
|
| 10MG | ￥4266 | 有现货 |
|
| 25MG | ￥6036 | 有现货 |
|
| 50MG | ￥7403 | 有现货 |
|
| 100MG | ￥9630 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥3696 | 有现货 |
|
生物学信息
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产品名称VTP50469
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VTP50469 是一种高选择性、口服活性的 Menin-MLL 相互作用抑制剂 (Ki: 104 pM)，具有有效的抗白血病活性。
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产品描述VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
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体外实验——
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体内实验Animal Model:Unconditioned immunodeficient (NSG) mice with MV4;11 cells Dosage:15 mg/kg, 30 mg/kg, and 60 mg/kg Administration:Oral administration; twice a day; for 28 days Result:Was highly efficacious across all dosage levels and all treatment groups had a significant survival advantage over the control group.
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis|Menin-MLL interaction
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研究领域——
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适应症——
化学信息
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CAS Number2169916-18-9
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分子量630.82
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分子式C32H47FN6O4S
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL (198.15 mM; Need ultrasonic)
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SMILESCC(C)N(C(C)C)C(=O)C1=C(C=CC(=C1)F)OC2=CN=CN=C2N3CC4(C3)CCN(CC4)CC5CCC(CC5)NS(=O)(=O)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Krivtsov AV, et al. A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia. Cancer Cell. 2019 Dec 9;36(6):660-673.e11.
产品手册
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