KI-7 ( —— )

产品货号. M23641 CAS No. 1489263-00-4

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产品名称

KI-7
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

KI-7 是一种腺苷 A2B 受体正变构调节剂。
产品描述

KI-7 is an adenosine A2B receptor positive allosteric modulator.
体外实验

KI-7 (1 μM; 5-21 days; mesenchymal stem cells) induces a significant increase in mRNA expression of Runx2 and Osterix.KI-7 (1 μM; 15-21 days) induced a significant increase in cell viability in both differentiation stages.KI-7, as A2B adenosine receptor positive allosteric modulator in MSCs, demonstrating it is able to potentiate the effects of either adenosine and synthetic orthosteric A2B adenosine receptor agonists in mediating osteoblast differentiation in vitro. NECA, BAY 60-6583 and KI-7 induce a strong increase in IL-6 production. KI-7 is able to potentiate the effects of orthosteric agonists in both differentiation stages, even if the effect became significant only at 21 days.
体内实验

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同义词

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通路

Apoptosis
靶点

Adenosine Receptor
受体

A2B
研究领域

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适应症

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1.Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203.

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