GR-79236

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性腺苷 A1 受体激动剂，Ki 为 3.1 nM。

A potent and selective Adenosine A1 receptor agonist with Ki of 3.1 nM; exerts profound antilipolytic effects with minimal effects on blood pressure and heart rate; orally active.

GR79236 inhibits Isoprenaline-stimulated cAMP accumulation in DDT-MF2 cells with an IC50 of 2.6 nM. GR79236 inhibits catecholamine-induced lipolysis in human, rat and dog isolated adipocytes.

GR79236 decreases locomotor activity and inhibits DMCM-induced seizures in mice (ED50s of 0.13 mg/kg and 0.3 mg/kg, respectively). Oral administration of GR79236 (0.1-10 mg/kg) to fed rats induces minimal changes in the plasma concentration of non-esterified fatty acids and in the blood concentrations of glucose and lactate. Intravenous infusion of GR79236 to fasted pithed rats, or oral administration of GR79236 to fasted conscious rats and dogs, produces time- and dose-dependent decreases in the plasma non-esterified fatty acid concentration. In the fasted rats, doses of GR79236 that lowered plasma levels of non-esterified fatty acids also produced hypotriglyceridaemia and anti-ketotic effects.

GR-79236X | GR79236

Apoptosis

Adenosine Receptor

Adenosine Receptor

Inflammation/Immunology

——

124555-18-6

351.3577

C15H21N5O5

>98% (HPLC)

H2O: ≥ 100 mg/mL

O[C@H]1[C@H](N2C=NC3=C(N[C@@H]4[C@@H](O)CCC4)N=CN=C23)O[C@H](CO)[C@H]1O

Adenosine, N-[(1S,2S)-2-hydroxycyclopentyl]-

(-20℃)

With Ice Pack

≥ 2 years