Hamaudol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hamaudol 是从防风中分离得到的色酮，具有镇痛和抗炎活性，对 COX-1 和 COX-2 活性具有抑制活性，其抑制值分别为 0.30、0.57 mM。当归根的 CHCl3 提取物显示对人胃腺癌 (MK-1) 细胞生长具有高抑制活性。

Hamaudol is a chromone isolated from Saposhnikovia divaricata,has analgesic and anti-inflammary activities, it showed inhibitory activity on COX-1 and COX-2 activities with values of 0.30, 0.57 mM, respectively.The CHCl3 extract of the root of Angelica japonica showed high inhibitory activity against human gastric adenocarcinoma (MK-1) cell growth. From this extract, a new furanocoumarin named japoangelone and four furanocoumarin ethers of falcarindiol, named japoangelols A-D, were isolated together with caffeic acid methyl ester, four polyacetylenic compounds (panaxynol, falcarindiol, 8-O-acetylfalcarindiol, and (9Z)-1,9-heptadecadiene-4,6-diyne-3,8,11-triol), eight coumarins (osthol, isoimperatorin, scopoletin, byakangelicin, xanthotoxin, bergapten, oxypeucedanin methanolate, and oxypeucedanin hydrate), and two chromones (3'-O-acetylHamaudol, and Hamaudol).

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Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency.

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Chromatin/Epigenetic

COX

COX-1|COX-2

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735-46-6

276.3

C15H16O5

>98% (HPLC)

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OC1=C2C(OC(C)(C)[C@@H](O)C2)=CC3=C1C(C=C(C)O3)=O

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(-20℃)

With Ice Pack

≥ 2 years