Flurbiprofen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

非甾体类抗炎药（NSAID）；主要用作术前抗缩瞳药以及口服治疗关节炎或牙痛；环氧合酶（COX）抑制剂。

A non-steroidal anti-inflammatory drug (NSAID); primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain; cyclooxygenase (COX) inhibitor.Pain Approved(In Vitro):Flurbiprofen (2-20 nM; 12-48 hours) significantly decreases SW620 cells proliferation in a concentration- and time-dependent manner.Flurbiprofen (10 nM; 24 hours) decreases COX-2 expression.Flurbiprofen (10 nM; 24 hours) inhibits the expression of inflammatory factors by inhibiting COX-2.Flurbiprofen (10 nM; 24 hours) promotes the apoptosis of colorectal cancer cells by inhibiting COX-2.(In Vivo):Flurbiprofen (0.3-4.8 mg/kg; p.o.; 4-5 dosages) has acute anti-inflammatory in adrenalectomized rats.Flurbiprofen (10 mg/kg; i.p.; daily; for 6 days) attenuates high-fat diet-induced obesity in mice.

Flurbiprofen (2-20 nM; 12-48 hours) significantly decreases SW620 cells proliferation in a concentration- and time-dependent manner.Flurbiprofen (10 nM; 24 hours) decreases COX-2 expression.Flurbiprofen (10 nM; 24 hours) inhibits the expression of inflammatory factors by inhibiting COX-2.Flurbiprofen (10 nM; 24 hours) promotes the apoptosis of colorectal cancer cells by inhibiting COX-2.Cell Proliferation Assay Cell Line:SW620 cells Concentration:2 nM, 4 nM, 10 nM, 20 nM Incubation Time:12 hours, 24 hours, 48 hours Result:Inhibited colorectal cancer cell proliferation.Western Blot Analysis Cell Line:SW620 cells Concentration:10 nM Incubation Time:24 hours Result:Significantly decreased the protein and mRNA levels of COX-2.RT-PCR Cell Line:SW620 cells Concentration:10 nM Incubation Time:24 hours Result:Decreased COX-2mRNA expression levels Apoptosis Analysis Cell Line:SW620 cells Concentration:10 nM Incubation Time:24 hours Result:Significantly decreased the expression of Bcl2 and significantly increased the expression of Bax and cleaved-caspase3, with no effect on total caspase-3.

Flurbiprofen (0.3-4.8 mg/kg; p.o.; 4-5 dosages) has acute anti-inflammatory in adrenalectomized rats.Flurbiprofen (10 mg/kg; i.p.; daily; for 6 days) attenuates high-fat diet-induced obesity in mice. Animal Model:Rat Dosage:0.3 mg/kg, 0.6 mg/kg, 1.2 mg/kg, 2.4 mg/kg, 4.8 mg/kg Administration:Oral administration, 4-5 dosages Result:Inhibited the acute inflammation.

±)-Flurbiprofen

Chromatin/Epigenetic

COX

COX|MRP

Neurological Disease

Pain

5104-49-4

244.2609

C15H13FO2

>98% (HPLC)

10 mM in DMSO

CC(C1=CC=C(C2=CC=CC=C2)C(F)=C1)C(O)=O

2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years