COX-2-IN-6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

COX-2-IN-6 (compound 10) 是一种口服有效、肠道限制性和选择性的环氧化酶-2 (COX-2) 抑制剂，用于结直肠癌的化学预防。COX-2-IN-6 选择性靶向 COX-2，IC50 为 0.84 μM，Ki 为 69 nM。COX-2-IN-6 还抑制 COX-2 驱动的 PGE2 合成，IC50 为 0.60 μM。

COX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.

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Animal Model:APCmin/+ mouse model Dosage:30 mg/kg, 100 mg/kg, 300 mg/kg Administration:PO; daily in chow diet Result:Significantly decreased [18F]-FDG uptake and polyp area.

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Chromatin/Epigenetic

COX

COX | Prostaglandin Receptor

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2756347-91-6

409.5

C20H27NO6S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (244.20 mM; 超声助溶 )

O(CC(C)(C)O)C1=C(C=C(CO)C(OCCC)=N1)C2=CC=C(S(C)(=O)=O)C=C2

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(-20℃)

With Ice Pack

≥ 2 years