Raphin1 acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Raphin1acetate 是一种选择性的、口服生物可利用的调节性磷酸酶 PPP1R15B (R15B) 抑制剂。Raphin1，一种选择性的 R15B 抑制剂。在细胞中，Raphin1 导致其磷酸化底物快速而短暂地积累，从而导致蛋白质合成短暂减弱。

Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B.?In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.?In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.?

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Metabolic Enzyme/Protease

Phosphatase

phosphatase?PPP1R15B (R15B)

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2242616-04-0

291.13

C10H12Cl2N4O2

>98% (HPLC)

DMSO:40 mg/mL?(137.4 mM;?Need ultrasonic)

CC(O)=O.NC(=N)N\N=C\c1cccc(Cl)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years