Procyanidin C1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

原花青素 C1 是一种天然产物，具有抗炎作用，并诱导细胞凋亡。

Procyanidin C1 is a natural product with anti-inflammatory effects and induces apoptosis.

Cell Cycle Analysis Cell Line:MCF-7 and MDA-MB-231 cell lines Concentration:35 μg/mL Incubation Time:48 h Result:Induced the cell cycle arrest at the S-phase in MCF-7 and MDA-MB-231 cell lines.Cell Cytotoxicity Assay Cell Line:MCF-7 and MDA-MB-231 cell lines Concentration:6.25-100 μg/mL Incubation Time:48 h Result:Inhibited cell proliferation of MCF-7 and MDA-MB-231 cells with IC50 values of 31.5 and 36.6 μg/mL and showed a higher cytotoxic activity to MDA-MB-231 than tamoxifen.

Animal Model:Non-obese diabetes and severe combined immunodficiency mice with PSC27 and PC3 cancer cells injection, and pre-treated with mitoxantrone (MIT) Dosage:20 mg/kg Administration:Intraperitoneal injection; 20 mg/kg; 2 weeks after the first MIT dose and then delivered biweekly Result:Remarkably enhanced tumour regression (55.2% reduction in tumour size compared with MIT alone; 74.9% reduction in tumour volume compared with the placebo treatment) and depleted the majority of senescent cells in chemotherapy treated animals.Animal Model:24-27 months of age mice (both sexes)Dosage:20 mg/kg Administration:Oral gavage; 20 mg/kg; for three consecutive days Result:Enhanced the median post-treatment lifespan with 64.2% and decreased the mortality hazard than the vehicle-treated group.

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Apoptosis

Apoptosis

Apoptosis

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37064-30-5

866.77

C45H38O18

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (115.37 mM)

[H][C@]1([C@@H](O)[C@H](Oc2cc(O)cc(O)c12)c1ccc(O)c(O)c1)c1c(O)cc(O)c2c1O[C@@H]([C@H](O)[C@@]2([H])c1c(O)cc(O)c2C[C@@H](O)[C@H](Oc12)c1ccc(O)c(O)c1)c1ccc(O)c(O)c1

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(-20℃)

With Ice Pack

≥ 2 years