C-178

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

C-178 是 STING 的共价抑制剂，与 STING 上的 Cys91 结合以阻断其棕榈酰化，并防止 HEK293T 细胞中 TBK1 的募集和磷酸化。

C-178 is a covalent inhibitor of STING binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells.

Western Blot Analysis Cell Line:Mouse bone marrow-derived macrophages (BMDMs)Concentration:0 μM; 0.125 μM; 0.25 μM; 0.5 μM; 1 μM Incubation Time:1 hour Result:Inhibited CMA-induced p-TBK1 expression as a does dependent manner.RT-PCR Cell Line:Mouse bone marrow-derived macrophages (BMDMs)Concentration:1 μM Incubation Time:1 hour Result:Downregulated Ifnb1 expression in BMDMs.

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Immunology/Inflammation

STING

mSTING

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329198-87-0

322.27

C17H10N2O5

>98% (HPLC)

In Vitro:?DMSO : 41.67 mg/mL (129.30 mM)

[O-][N+](=O)c1ccc(o1)C(=O)Nc1ccc2c(c1)oc1ccccc21

N-(Dibenzo[bd]furan-3-yl)-5-nitrofuran-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years