2'3'-cGAMP ( —— )

产品货号. M19382 CAS No. 1441190-66-4

2',3'-cGAMP (2'-3'-环状 GMP-AMP) 是哺乳动物细胞中的内源性 cGAMP。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

2'3'-cGAMP
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

2',3'-cGAMP (2'-3'-环状 GMP-AMP) 是哺乳动物细胞中的内源性 cGAMP。
产品描述

2'3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2'3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2'3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm.2’3’-cGAMP is also referred to as “noncanonical“ cGAMP due to the presence of the atypical 2’-5’ phosphodiester linkage between the guanosine and the adenosine.Similar to the canonical 3’3’-cGAMP 2’3’-cGAMP serves as a second messenger to activate innate immune responses by binding to STING (stimulator of IFN genes) and subsequently inducing the TBK1-IRF3-dependent production of IFN-β . Structural and functional studies revealed that noncanonical 2’3’-cGAMP is distinct from the canonical 3’3’-cGAMP produced by bacteria [23]. 2'3'-cGAMP binds to STING with a much greater affinity than 3'3'-cGAMP.Certain variants of STING are able to distinguish between noncanonical and canonical cGAMP.
体外实验

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) contains two distinct phosphodiester linkages, one between 2′-OH of GMP and 5′-phosphate of AMP, and the other between 3′-OH of AMP and 5′-phosphate of GMP.
体内实验

——
同义词

——
通路

Immunology/Inflammation
靶点

STING
受体

STING
研究领域

——
适应症

——

化学信息

CAS Number

1441190-66-4
分子量

674.41
分子式

C??H??N??O??P?
纯度

>98% (HPLC)
溶解度

Soluble in DMSO
SMILES

OC1([H])[C@](OP(O)(OC[C@](O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]4O)([H])[C@@]4([H])O5)=O)([H])[C@H](N6C(NC(N)=NC7=O)=C7N=C6)O[C@]1([H])COP5(O)=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Zhang X. et al. 2013. Cyclic GMP-AMP containing mixed phosphdiester linkages is an endogenous high-affinity ligand for STING. Mol Cell.51(2):226-35. 2. Diner E. et al. 2013. The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING. Cell Rep. 3(5):1355-61. 3. Gao P. et al. 2013. Cyclic [G(2'5')pA(3'5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell. 153(5):1094-107.

计算器

浓度计算器

摩尔计算器

分子量计算器

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