Piclidenoson

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Piclidenoson 是一种选择性腺苷 A3 受体激动剂（EC50 值为 0.11 μM），对银屑病患者具有强大的抗炎作用。

Piclidenoson a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM) induces robust anti-inflammatory effect in psoriasis patients.

Cell Proliferation Assay Cell Line:OVCAR-3 cells, Caov-4 cells Concentration:0.0001-100 μM Incubation Time:48 hours Result:Resulted in a dose-dependent reduction in the cell viability.Apoptosis Analysis Cell Line:OVCAR-3 cells, Caov-4 cells Concentration:0.1 μM, 1 μM, 10 μM, 50 μM, 100 μM Incubation Time:48 hours Result:Significant increased in the percentage of apoptosis in a concentration-dependent manner.Western Blot Analysis Cell Line:OVCAR-3 cells, Caov-4 cells Concentration:1 μM, 10 μM, 100 μM Incubation Time:48 hours Result:Decreased the expression of Bcl-2 was noticeably and increased the expression of Bax protein.

Animal Model:B10CBAF1 male mice aged 3 months (average 30 g)Dosage:105 μg/kg Administration:Intraperitoneal injection, 0.5 h after irradiation Result:Resulted in statistically significant increases of the mean survival time in comparison with the control irradiated mice.

IB-MECA | CF-101

Apoptosis

Adenosine Receptor

A3

Inflammation/Immunology

Plaque psoriasis; Rheumatoid arthritis

152918-18-8

510.29

C18H19IN6O4

>98% (HPLC)

DMSO:45 mg/mL (88.19 mM)

CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12

(2S3S4R5R)-34-dihydroxy-5-(6-(3-iodobenzylamino)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide

(-20℃)

With Ice Pack

≥ 2 years