idalopirdine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Idalopirdine，一种选择性 5-HT6 受体拮抗剂（Ki：0.83 nM），用于治疗阿尔茨海默病。

Idalopirdine a selective 5-HT6 receptor antagonist(?Ki : 0.83 nM)as a treatment for Alzheimer's disease.

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Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models.Idalopirdine (1 or 2?mg/kg, i.v) can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats. Animal Model:Male Wistar ratsDosage:5?mg/kgAdministration:intraperitoneal injection, daily, 28 daysResult:Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol.Animal Model:Male Sprague-Dawley rats Dosage:1 or 2?mg/kgAdministration:i.v.Result:No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg.Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration.

Lu AE58054

Endocrinology/Hormones

5-HT Receptor

5-HT6

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467459-31-0

398.37

C20H19F5N2O

>98% (HPLC)

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FC(F)C(F)(F)COc1cccc(CNCCc2c[nH]c3cc(F)ccc23)c1

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(-20℃)

With Ice Pack

≥ 2 years