m-Chlorophenylbiguanide hydrochloride ( 1-(3-Chlorophenyl)biguanidehydrochloride )

产品货号. M27652 CAS No. 2113-05-5

m-Chloro苯基双胍盐酸盐是一种 5-HT3 受体激动剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
50MG	￥114	有现货
100MG	￥147	有现货
500MG	￥349	有现货
1G	￥512	有现货

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生物学信息

产品名称

m-Chlorophenylbiguanide hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

m-Chloro苯基双胍盐酸盐是一种 5-HT3 受体激动剂。
产品描述

m-Chlorophenylbiguanide hydrochloride is a 5-HT3 receptor agonist. m-Chlorophenylbiguanide hydrochloride selectively binds 5-HT3(Ki: 0.002 μM) over 5-HT1A(Ki: 10 μM) and 5-HT2(Ki: 10 μM) receptors but also binds to high and low affinity sites on the dopamine transporter(DAT; IC50s: 0.4 and 34.8 μM, respectively, in rat caudate putamen synaptosomal membranes).(In Vivo):m-Chlorophenylbiguanide hydrochloride induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 μM, respectively).m-Chlorophenylbiguanide hydrochloride induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).
体外实验

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体内实验

Animal Model:Wistar male ratsDosage:80, 160 and 320 nM Administration:Ventricle injection Result:Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
同义词

1-(3-Chlorophenyl)biguanidehydrochloride
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

——
研究领域

——
适应症

——

化学信息

CAS Number

2113-05-5
分子量

248.11
分子式

C8H11Cl2N5
纯度

>98% (HPLC)
溶解度

In Vitro:?H2O : 125 mg/mL (503.81 mM)
SMILES

Cl.NC(=N)NC(=N)Nc1cccc(Cl)c1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Tsuji H, Eto T, Sakamoto Y. Synthesis and Hydrolytic Degradation of Substituted Poly(DL-Lactic Acid)s. Materials (Basel). 2011 Aug 10;4(8):1384-1398.

计算器

浓度计算器

摩尔计算器

分子量计算器

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