Medroxyprogesterone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Medroxyprogesterone是合成的人孕酮变体，是孕酮受体激动剂。

Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator.

Cell Proliferation Assay Cell Line:T47D Concentration:10 nM Incubation Time:24 h, 48 h, 72h Result:Increased the number of cells at 48 h.Western Blot Analysis Cell Line:T47D Concentration:10 nM Incubation Time:4 h Result:Induced the expression of Cyclin D1 protein.RT-PCR Cell Line:HUVECs Concentration:100 nM Incubation Time:24 h Result:Increased mRNA and protein expression of adhesion molecules.

Animal Model:ApoE-/- mice model Dosage:27.7 μg/day Administration:s.c.Result:Reduced atherosclerotic plaque and increased thrombosis.

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Endocrinology/Hormones

Estrogen Receptor/ERR

Estrogen/progestogen Receptor

Inflammation/Immunology

Autoimmune haemolytic anaemia; Crohn's disease; Idiopathic thrombocytopenic purpura; Ulcerative colitis

520-85-4

344.49

C22H32O3

>98% (HPLC)

DMSO:197.4 mM

C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12

Pregn-4-ene-320-dione 17-hydroxy-6-alpha-methyl-

(-20℃)

With Ice Pack

≥ 2 years