Megestrol acetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Megestrol acetate 是具有口服活性的、合成孕激素。Megestrol acetate 可作为食欲刺激素，用于消瘦综合征如恶病质的研究。Megestrol acetate 可下调细胞核和细胞质雄激素受体 (androgen receptors) 的活性。Megestrol acetate 可用于 HIV 的研究并下调自噬分解代谢途径。

Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. It also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast Y. Megestrol acetate has been approved to treat anorexia and cachexia. (In Vitro):Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line.

Megestrol acetate alone results in an ICKY of 48.7 p,M in the MCF7/ADR cell line.

Megestrol acetate (100 or 300 mg/kg, Subcutaneously daily over a 7-day period) is able to reduce the weight loss produced by both TNF and by the MAC16 tumour. Animal Model:Pure strain female NMRI mice (age 6 to 8 weeks).Dosage:100 or 300 mg/kg (50 mg megestrol acetate was suspended in 3 ml of pure corn oil).Administration:Subcutaneously daily over a 7-day period.Result:Produced a highly significant reversal of the TNF-induced decrease in body weight, accompanied by a significant increase in both food and water intake.Caused an increase in body weight over a 24-hour period to female NMRI mice.No effect on blood glucose levels in saline controls, concurrent administration of megestrol acetate with TNF caused a significant increase in blood glucose compared with administration of TNF alone.Caused a dose-related reduction in the loss of host body weight in animals bearing the MAC16 tumour.

Megestrol Acetate | NSC 71423 | SC-10363

Endocrinology/Hormones

Estrogen Receptor/ERR

ER| Glucocorticoid Receptor

Endocrinology

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595-33-5

384.51

C24H32O4

>98% (HPLC)

Ethanol: 15 mg/mL (39.01 mM); DMSO: 33 mg/mL (85.82 mM)

CC(O[C@]1(C(C)=O)CC[C@@]2([H])[C@]3([H])C=C(C)C4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O

(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

(-20℃)

With Ice Pack

≥ 2 years