17α-Estradiol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

内源性雌激素受体配体（ERα 和 ERβ 受体的 Ki 值分别为 0.2 和 1.2 nM）。

Endogenous estrogen receptor ligand (Ki?values are 0.2 and 1.2 nM for ERα?and ERβ?receptors respectively).

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.

Alfatradiol | Epiestradiol | Epiestrol

Endocrinology/Hormones

5-HT Receptor

ERα| ERβ

Others-Field

——

57-91-0

272.38

C18H24O2

>98% (HPLC)

DMSO : 103.3 mg/mL 379.25 mM

c1cc(cc2CC[C@H]3[C@@H]4CC[C@H]([C@]4(CC[C@@H]3c12)C)O)O

——

(-20℃)

With Ice Pack

≥ 2 years