Polyphyllin I

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Polyphyllin D 通过线粒体凋亡途径诱导细胞凋亡，具体表现为 Bcl-2 表达水平降低、MMP 破坏以及 Bax、细胞色素 C 和 cleaved-caspase-3 水平升高。

Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.

Cell Proliferation Assay Cell Line:A549, H460, and SK-MES-1 cells Concentration:24, 48, 72 hours Incubation Time:24, 48, 72 hours Result:Markedly reduced proliferation capacity in vitro and in a concentration-dependent manner.

Animal Model:BALB/c nude mice (5 weeks old) were s.c. inoculated with A549 cells Dosage:1.5 mg/kg Administration:I.p. twice daily from day 2 to day 11 Result:The tumor growth rate was much lower than that in cisplatin group and PBS group.

——

Apoptosis

NF-κB

Others

Others-Field

——

50773-41-6

855.03

C44H70O16

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (116.96 mM)

[C@@H]1([C@@H]([C@@H]([C@H]([C@@H](O1)C)O)O)O)O[C@H]1[C@@H](O[C@@H]([C@H]([C@@H]1O)O[C@@H]1O[C@H]([C@@H]([C@H]1O)O)CO)CO)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6([C@H]([C@@H]5[C@]4(CC[C@@H]3[C@]2(CC1)C)C)C)CC[C@H](CO6)C

——

(-20℃)

With Ice Pack

≥ 2 years