CHPG sodium salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CHPG sodium salt 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG sodium salt 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..

Cell Viability Assay Cell Line:BV2 microglial cells Concentration:10, 50, 100 and 500?μM Incubation Time:24?hours Result:Increased the cell viability. Apoptosis Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Protected BV2 cells against SO2-induced apoptosis.Western Blot Analysis Cell Line:BV2 microglial cells Concentration:0.5?mM Incubation Time:30?mins Result:Increased the expression of TSG-6 in both mRNA and protein levels.

Animal Model:Adult Sprague-Dawley male rats weighing 280-320 g Dosage:250 nM Administration:Injection; for 7 days Result:Reduced significantly cerebral lesion volume.

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Apoptosis

NF-κB

NF-κB | GluR

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1303993-73-8

223.59

C8H7ClNNaO3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (447.25 mM; 超声助溶 ) H2O 中的溶解度 : 6.67 mg/mL (29.83 mM; 超声助溶 (<80°C)

C1=CC(=C(C=C1O)C(C(=O)[O-])N)Cl.[Na+]

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(-20℃)

With Ice Pack

≥ 2 years