Isodeoxyelephantopin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

异脱氧象皮素能抑制多种肿瘤细胞的生长。

Isodeoxyelephantopin can inhibit the growth of various tumor cells.(In Vitro):Isodeoxyelephantopin inhibits the growth of A549 and T47D cells in a dose-dependent and time-dependent manner with IC50 values of 10.46 and 1.3 μg/mL, respectively. Heterodeoxyelephantin showed no significant toxicity to normal lymphocytes. Heterodeoxyelephinin-induced cell death is associated with activated caspase-3 expression, followed by cell cycle stagnation in G2/M phase .

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop.

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Apoptosis

NF-κB

NF-κB

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38927-54-7

344.363

C19H20O6

>98% (HPLC)

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CC(=C)C(=O)O[C@H]1CC2=C[C@H](C\C(C)=C/[C@H]3OC(=O)C(=C)[C@H]13)OC2=O

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(-20℃)

With Ice Pack

≥ 2 years