Gamabufotalin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gamabufotalin 是 Chansu 的主要蟾蜍二烯内酯，由于其理想的代谢稳定性和较少的不良反应，已被用于治疗 COX-2 介导的疾病和癌症治疗。

Gamabufotalin , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.

Apoptosis Analysis Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Increase the expression levels of the cleaved caspase-3, caspase-9 and PARP.Induced the release of cyt c from mitochondria to cytosol.Immunofluorescence Cell Line:A549 cells Concentration:0-100 nM Incubation Time:12-48 h Result:Inhibited translocation of the NF-κB p65/p50 proteins from cell cytoplasm to nucleus, and induced p300 into the cytoplasm.

Animal Model:A549-xenografts miceDosage:5 and 20 mg/kg/day Administration:i.p., for 17 days Result:Reduced tumor volume and the tumor weights.Decreased COX-2 and p-p65 level in tumors.

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Endocrinology/Hormones

5-HT Receptor

COX-2

Cancer

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465-11-2

402.53

C24H34O5

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (124.22 mM)

CC12CCC(CC1CCC3C2C(CC4(C3(CCC4C5=COC(=O)C=C5)O)C)O)O

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(-20℃)

With Ice Pack

≥ 2 years