RS 102221

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种高效、选择性 5-HT2C 受体拮抗剂，对人和大鼠 5-HT2C 的 pKi 分别为 8.4 和 8.5。

A highly potent, selective 5-HT2C receptor antagonist with pKi of 8.4 and 8.5 for human and rat 5-HT2C, respectively; demonstrates 100-fold selectivity for the 5-HT2C versus 5-HT2A and 5-HT2B receptors; acts as an antagonist in a cell-based microphysiometry functional assay with pA2 of 8.1 and has no detectable intrinsic efficacy; increases food-intake and weight-gain in rats (2 mg/kg, i.p.); reverses the inhibitory effects of MK-212 and DOI on 'monosynaptic and 'intermediate' neurones.

Cell Differentiation Assay Cell Line:Mouse adult hippocampal neural progenitor cells (ahNPCs)Concentration:0.3, 1, 10, 30, 100, and 300 nM Incubation Time:24 hours Result:Significantly increases the percentage of MAP-2+ cells at 10 nM.

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RS102221 | RS-102221

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

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187397-18-8

649.08

C27H31F3N4O7S.HCl

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (192.58 mM)

O=S(C1=CC=C(C(F)(F)F)C=C1)(NC2=CC(C(CCCCN(CC3)CCC3(NC(N4)=O)C4=O)=O)=C(OC)C=C2OC)=O.[H]Cl

8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione hydrochloride

(-20℃)

With Ice Pack

≥ 2 years