MonoMethyl auristatin F ( Monomethyl auristatin F | MMAF )

产品货号. M17587 CAS No. 745017-94-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MonoMethyl auristatin F
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Monomethyl auristatin F 是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂。
产品描述

Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab mafodotin and SGN-CD19A. In International Nonproprietary Names for MMAF-antibody-conjugates, the name mafodotin refers to MMAF plus its attachment structure to the antibody. MMAF is actually desmethyl-auristatin F; that is, the N-terminal amino group has only one methyl substituent instead of two as in auristatin F itself.
体外实验

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体内实验

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同义词

Monomethyl auristatin F | MMAF
通路

Cell Cycle/DNA Damage
靶点

Potassium Channel
受体

Cytotoxicity( Karpas 299 cell)
研究领域

Cancer
适应症

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CAS Number

745017-94-1
分子量

731.98
分子式

C39H65N5O8
纯度

>98% (HPLC)
溶解度

——
SMILES

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
化学全称

((2R,3R)-3-((2S)-1-((3R,5S)-4-((S)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine

1. Tai, Y. T.Blood. 123 (20): 3128–38.

计算器

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