PAP-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PAP-1 是一种选择性、口服活性的 Kv1.3 阻滞剂 (EC50: 2 nM)。

PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).

PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM. Cell Proliferation Assay Cell Line:CCR7-TEM cells (anti-CD3 Ab stimulated)Concentration:2, 10, 25, 100 nM Incubation Time:30 minutes Result:Suppresses the Proliferation of CCR7-TEM cells with IC50 of 10 nM.

PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats. Animal Model:9- to 11- week-old female Lewis rats Dosage:Intraperitoneal injection; three times daily for 48 hours Administration:0.3, 1, 3 mg/kg Result:Dose-dependently suppressed the DTH reaction.

5-(4-Phenoxybutoxy)psoralen

Cell Cycle/DNA Damage

Potassium Channel

Kv1.3 channels

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870653-45-5

350.36

C21H18O5

>98% (HPLC)

DMSO:48 mg/mL (137 mM; Need ultrasonic);Water:Insoluble

O=C(C=C1)Oc2c1c(OCCCCOc1ccccc1)c(cco1)c1c2

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(-20℃)

With Ice Pack

≥ 2 years