Ro 67-7476

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ro 67-7476 是 mGlu1 受体的正变构调节剂。对人类 mGlu1 受体没有活性。增强谷氨酸诱导的钙释放，EC 50 为 60.1 nM。

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.

In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5.?Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM). The EC50?value of? full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC50 for calcium mobilization potentiation.Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC50?value of 17.7 μM.

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Endocrinology/Hormones

5-HT Receptor

mGluR1

Neurological Disease

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298690-60-5

319.39

C17H18FNO2S

>98% (HPLC)

DMSO : ≥ 40 mg/mL; 125.24 mM

N1([C@@H](CCC1)c1ccc(cc1)F)S(=O)(=O)c1ccc(cc1)C

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(-20℃)

With Ice Pack

≥ 2 years