VA-012 ( VA012 )

产品货号. M16412 CAS No. 885898-58-8

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HNMR

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MSDS

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产品名称

VA-012
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

VA-012 是一种有效的选择性 5-HT2C 受体正变构调节剂 (PAM)，具有剂量依赖性的 5-HT 功效增强作用，EC50 为 16 nM。
产品描述

VA-012 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM) that exhibits dose-dependent potentiation of 5-HT efficacy with EC50 of 16 nM; shows no significant off-target activities, and low binding competition with serotonin or other orthosteric ligands; increases the anorectic effect combined with the SSRI sertraline; reduces food intake and body weight gain without causing CNS-related malaise.
体外实验

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体内实验

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同义词

VA012
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

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适应症

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1. García Cárceles J, et al. J Med Chem. 2017 Nov 8. doi: 10.1021/acs.jmedchem.7b00994.

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