CNX-774 ( CNX774 | CNX 774 | CNX-774 )

产品货号. M17187 CAS No. 1202759-32-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CNX-774
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CNX-774 是一种高度特异性、不可逆、口服活性的 BTK 抑制剂 (IC50<1 nM)。
产品描述

CNX-774 is a potent Btk inhibitor (IC50 < 1 nM). Recently Bruton's tyrosine kinase (BTK) , a crucial terminal kinase enzyme in the B-cell antigen receptor (BCR) signaling pathway, has emerged as an attractive target for therapeutic intervention in human malignancies and autoimmune disorders.
体外实验

CNX-774 strongly inhibits Btk activity in Ramos cells with an IC50 of 1-10 nM. CNX-774 demonstrates strong time- and dose-dependent occupancy of Btk in Ramos cells.
体内实验

CNX-774 is stable and non-reactive in fresh human and rat whole blood and does not covalently bond to any of the mid-level abundance human plasma proteins.CNX-774 demonstrates potent inhibitory activity towards the intended target, Btk, while achieving remarkable specificity in a variety of assays designed to assess off-target reactivity towards abundant cellular thiols and blood proteins.
同义词

CNX774 | CNX 774 | CNX-774
通路

Apoptosis
靶点

Apoptosis
受体

BTK
研究领域

Cancer
适应症

——

CAS Number

1202759-32-7
分子量

499.5
分子式

C26H22FN7O3
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 45 mg/mL. 90.09 mM
SMILES

c1c(ccc(c1)Oc1ccnc(c1)C(=O)NC)Nc1nc(c(cn1)F)Nc1cccc(c1)NC(=O)C=C
化学全称

4-(4-((4-((3-acrylamidophenyl)amino)-5-fluoropyrimidin-2-yl)amino)phenoxy)-N-methylpicolinamide

1. Labenski M. 17th North Am Meet Int Soc Study Xenobiot (ISSX) 2011. Abst. P211.

计算器

产品手册

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