W146

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

W146 是 1-磷酸-鞘氨醇受体亚型 1 (S1PR1) 的选择性拮抗剂， EC50 值为 398 nM。

W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

W146 is a S1PR1 antagonist with a Ki of ~70-80 nM. W146 pretreatment significantly increases activated cleaved caspase-3 levels. The reduced EPCs apoptosis which induced by S1P is completely abolished after treatment with W146.

W146 (5 mg/kg, ip, prior to AMD3100 administration) pre-treatment shows approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony forming assays, compared to that in mice treated with AMD3100 aloneThe W146-mediated augmentation of KSL-HSPC mobilization is specific, because pretreatment of mice with W140 is unable to produce any effect on AMD3100-stimulated KSL-HSPC mobilization. Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count in mice.Animal Model:Mice (4-6-week-old).Dosage:5 mg/kg.Administration:IP, 1 hour prior to AMD3100 (ADM) administration. Result: Significantly increased in KSL-HSPC mobilization compared to that in mice pretreated with dextran followed by AMD3100 administration.

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Apoptosis

Apoptosis

Apoptosis | LPL Receptor

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909725-61-7

342.37

C16H27N2O4P

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 22.22 mg/mL (64.90 mM; 超声助溶 )

N(C([C@@H](CCP(=O)(O)O)N)=O)C1=CC(CCCCCC)=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years