CI-947

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种口服活性腺苷受体激动剂，可在体内诱导急性心血管毒性和冠状血管损伤。

An orally active adenosine receptor agonist that can induce acute cardiovascular toxicity and coronary vascular injury in vivo.

——

PD 117519 (2-10 mg/kg; oral administration; 16-24 hours; male beagle dogs) treatment produces significant hemodynamic changes at Tmax (4 hours) follows by acute coronary vascular injury that is evident at 16 hours postdosing.Treatment with 2 or 10 mg/kg of PD 117519 produces significant increases in mean heart rate and decreases in mean indirectsystolic blood pressure at time of highest drug exposure, 4 hours postdosing. Animal Model:24 male beagle dogs (8-12 months old)Dosage:2 mg/kg or 10 mg/kg Administration:Oral administration; 16 hours and 24 hours Result:Increased in mean heart rate and decreased in mean indirectsystolic blood pressure at time of highest drug exposure. Induced acute coronary arteriopathy. The endothelium also appears injured.

PD-117519 | PD 117519 | PD117519 | CI 947 | CI947

Apoptosis

Adenosine Receptor

Adenosine Receptor

Neurological Disease

——

96392-15-3

383.4012

C19H21N5O4

>98% (HPLC)

DMSO: ≥ 3.9 mg/mL

C1CC2=CC=CC=C2C1NC3=C4C(=NC=N3)N(C=N4)C5C(C(C(O5)CO)O)O

Adenosine, N-[(1R)-2,3-dihydro-1H-inden-1-yl]-

(-20℃)

With Ice Pack

≥ 2 years