Aceclofenac

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

醋氯芬酸是双氯芬酸的非甾体抗炎药 (NSAID) 类似物。

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. (In Vitro):Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes.Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test.Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.(In Vivo):Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg).Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg).

Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes.Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test.Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes.

Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg).Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg). Animal Model:Male Sprague-Dawley rats weighing 32-340 g Dosage:10 mg/kg for i.v., 20 mg/kg for p.o. (Pharmacokinetic Analysis) Administration:Oral administration and intravenous injection Result:T1/2 (3.24 h), Cmax (4.59 μg/mL for p.o.).

Aceclofenac | YT-919 | YT 919 | YT919 | Airtal | Beofenac

Chromatin/Epigenetic

COX

COX

Inflammation/Immunology

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89796-99-6

354.18

C16H13Cl2NO4

>98% (HPLC)

DMSO: 10 mM

O=C(OCC(O)=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

2-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)acetic acid

(-20℃)

With Ice Pack

≥ 2 years