Zaltoprofen

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Zaltoprofen 是一种 Cox-1 和 Cox-2 抑制剂，用于治疗关节炎。

Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.(In Vitro):Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner.Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells.Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.(In Vivo):Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats.Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner.

Zaltoprofen (0.1-10 μM; 15 min) inhibits thromboxane B2 production in human platelets in a dose-dependent manner.Zaltoprofen (0.01-1 μM; 30 min) inhibits prostaglandin E2 production by interleukin-1β-stimulated synovial cells.Zaltoprofen (0.1-1 μM; 5 min) inhibits the bradykinin-induced increase of [Ca2+]i in DRG cells.

Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats.Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner. Animal Model:Eight-week-old male Wistar rats were injected Bradykinin every 15 min Dosage:5, 10, 20 mg/kg Administration:A single p.o.Result:Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.The duration of analgesic effect was 60-90 min.

CN 100 | Soleton

Chromatin/Epigenetic

COX

COX-1| COX-2

Inflammation/Immunology

——

74711-43-6

298.36

C17H14O3S

>98% (HPLC)

Ethanol: 31 mg/mL (103.9 mM); DMSO: 60 mg/mL (201.09 mM)

O=C(O)C(C)C1=CC=C(C(C2)=C1)SC3=CC=CC=C3C2=O

10,11-Dihydro-alpha-methyl-10-oxodibenzo(b,f)thiepin-2-acetic acid

(-20℃)

With Ice Pack

≥ 2 years