Chlorotrianisene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chlorotrianisene 是一种强效合成非甾体雌激素。

Chlorotrianisene is a powerful synthetic, non-steroidal estrogen.(In Vitro):Comparison of intracellular estrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC50 of 28 nM and a Ki of 500 nM in MCF-7 cells.(In Vivo):The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [3H]estradiol (E2).

Comparison of intracellularestrogen receptor (ER) affinities of Chlorotrianisene with respective rat uterine cytosolic ER affinities has initially suggested the potential for activation of ER as a mechanism of growth stimulation. Chlorotrianisene exhibits concentration dependent cell growth stimulation with an EC50 of 28 nM and a Ki of 500 nM in MCF-7 cells.

The incubation of Chlorotrianisene with rat liver microsomes and NADPH generates a reactive intermediate which binds covalently to proteins. Intermediate may inactivate the uterine estrogen receptors (ER). The incubation of Chlorotrianisene with rat liver microsomes and NADPH in the presence of rat uteri, under conditions which generate intermediate, markedly decreased the binding capacity of the ER for [3H]estradiol (E2).

Chlorotrianisene | Chlortrianisestrol | Chlortrianizen | Chlorotrianisine | Chlorestrolo | Chlorotrianizen | Khlortrianizen

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Cancer

——

569-57-3

380.86

C23H21ClO3

>98% (HPLC)

DMSO: 10 mM

COC1=CC=C(C=C1)C(=C(C2=CC=C(C=C2)OC)Cl)C3=CC=C(C=C3)OC

1-[1-chloro-2,2-bis(4-methoxyphenyl)ethenyl]-4-methoxybenzene

(-20℃)

With Ice Pack

≥ 2 years