PHTPP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的、选择性的雌激素 ERβ 受体拮抗剂；对 ERβ 具有 36 倍的选择性，并且作为 ERα 拮抗剂完全有效。

A potent, selective antagonist of estrogen ERβ receptor; exhibits 36-fold selective for ERβ, and is fully effective as an ERα antagonist, while exhibiting no significant agonism on ERβ or Erα; enhances SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.

PHTPP is a selective ERβ antagonist. PHTPP reduces FSH-mediated cAMP production by 80% (p<0.01) while it has no effect on basal cAMP. PHTPP (10-6 M) inhibits E2-stimulated ERβ activity, but does not suppress E2-stimulated ERα activity. A high dose of PHTPP (10-6 M) slightly increases class 1 Igf1 mRNA expression, and facilitates the DPN-induced increase in class 1 Igf1 mRNA expression.

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PHTPP

Endocrinology/Hormones

Estrogen Receptor/ERR

ERβ

Cancer

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805239-56-9

423.3

C20H11F6N3O

>98% (HPLC)

DMSO: 14 mg/mL (33 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

OC1=CC=C(C2=C3N=C(C(F)(F)F)C=C(C(F)(F)F)N3N=C2C4=CC=CC=C4)C=C1

4-[2-Phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]phenol

(-20℃)

With Ice Pack

≥ 2 years