Procaine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

酯类局部麻醉剂，起效缓慢，作用持续时间短。主要用于浸润麻醉、周围神经阻滞、脊髓阻滞等。

A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.(In Vitro):Procaine hydrochloride (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale.

Procaine hydrochloride (0.01-100 microM) inhibited the 5-HT3 receptor-mediated inward current in the whole-cell patch clamp recording. Procaine appears to produce a competitive inhibition on 5-HT3 receptors with a KD of 1.7 microM. Procaine is a DNA-demethylating agent that produces a 40% reduction in 5-methylcytosine DNA content as determined by high-performance capillary electrophoresis or total DNA enzyme digestion. Procaine can also demethylate densely hypermethylated CpG islands. Procaine also has growth-inhibitory effects in these cancer cells, causing mitotic arrest. Procaine functions as an excitant of limbic system cells, and that procaine alters synaptic transmission in some, but not all, output pathways from the amygdale.

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Novocaine

Endocrinology/Hormones

5-HT Receptor

5-HT3| nAChR| NMDA receptor| Sodium channel

Neurological Disease

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51-05-8

272.77

C13H20N2O2·HCl

>98% (HPLC)

Water: 55 mg/mL (201.63 mM); DMSO: 55 mg/mL (201.63 mM)

O=C(OCCN(CC)CC)C1=CC=C(N)C=C1.[H]Cl

Benzoic acid, 4-amino-, 2-(diethylamino)ethyl ester, monohydrochloride

(-20℃)

With Ice Pack

≥ 2 years