Hinokitiol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Hinokitiol (4-Isotropictropolone;β-Thujaplicin) 是一种与托酚酮相关的天然化合物，可以诱导细胞凋亡和细胞周期停滞。

Hinokitiol (4-Isopropyltropolone;β-Thujaplicin) is a tropolone-related natural compound that can induces apoptosis and cell cycle arrest, exhibits anti-inflammatory and anti-tumor activities; inhibits the proliferation of Chlamydia trachomatis with MIC of 32 ug/mL; also can harness such gradients to restore iron transport into, within, and/or out of cells.

In U87MG and T98G glioma cell lines, hinokitiol demonstrates a dose-dependent decrease in viability, with IC50 values of 316.5 ± 35.5 and 152.5 ± 25.3 μM, respectively. Hinokitiol represses ALDH activity and self-renewal ability in glioma stem cells, and inhibits in vitro oncogenicity. Hinokitiol also reduces Nrf2 expression in glioma stem cells in a dose-dependent manner. Hinokitiol (0-100 μM) inhibits colon cancer cell growth in a dose- and time-dependent manner. Hinokitiol (5, 10 μM) decreases DNMT1 and UHRF1 mRNA and protein expression, and increases TET1 expression via enhancement of 5hmC level in HCT-116 cells. Furthermore, hinokitiol reduces methylation status and restores mRNA expression of MGMT, CHST10, and BTG4 genes.

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4-Isopropyltropolone | β-Thujaplicin

Apoptosis

Apoptosis

ERα

Neurological Disease

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499-44-5

164.204

C10H12O2

>98% (HPLC)

Chloroform: Soluble DMSO: 29 mg/mL (176.6 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

CC(C)C1=CC(=O)C(=CC=C1)O

2-hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one

(-20℃)

With Ice Pack

≥ 2 years