SR31527

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SR31527 是一种新型变构驱动蛋白样蛋白 KIFC1 抑制剂，可抑制微管刺激的 KIFC1 ATPase 活性，IC50 为 6.6 uM。

SR31527 is a novel allosteric Kinesin-like protein KIFC1 inhibitor that inhibits microtubule-stimulated KIFC1 ATPase activity with IC50 of 6.6 uM, binds directly to KIFC1 with Kd of 25.4 nM; prevents bipolar clustering of extra centrosomes in TNBC cells and significantly reducesTNBC cell colony formation and viability (MDA-MB-231, BT549 and MDA-MB-435s cells IC50=20-30 uM), with less toxicity to normal fibroblasts.

Cell Viability Assay Cell Line:MDA-MB-231, BT549, MDA-MB-435s cells Concentration:0-100 μM Incubation Time:96 h Result:Decreased cell viability with IC50s of 29, 33, 20 μM for MDA-MB-231, BT549, MDA-MB-435s cells, respectively.

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SR 31527 | SR-31527

Cytoskeleton/Cell Adhesion Molecules

Kinesin

Kinesin

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311814-78-5

319.807

C15H14ClN3OS

>98% (HPLC)

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COC1=CC=C(C2=[N+](C3=CC=CC=C3)SC(N)=N2)C=C1.[Cl-]

5-amino-3-(4-methoxyphenyl)-2-phenyl-1,2,4-thiadiazol-2-ium chloride

(-20℃)

With Ice Pack

≥ 2 years