CIL-56

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YAP1抑制剂CA3 (CA3;CIL56)是一种小分子，对YAP1/Tead转录活性具有显着的抑制活性。

YAP1 inhibitor CA3 (CA3;CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/Tead transcriptional activity; also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo; can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU; triggers nonapoptotic cell death, a potent and selective probe of ferroptosis; stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.

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YAP1 inhibitor CA3

Apoptosis

Ferroptosis

ROS

Other Indications

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300802-28-2

489.6

C23H27N3O5S2

>98% (HPLC)

DMSO: 88 mg/mL (179.7 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=S(C1=CC2=C(C=C1)C3=C(C=C(S(=O)(N4CCCCC4)=O)C=C3)/C2=N\O)(N5CCCCC5)=O

2,7-bis(piperidin-1-ylsulfonyl)-9H-fluoren-9-one oxime

(-20℃)

With Ice Pack

≥ 2 years