Cerivastatin sodium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cerivastatin sodium 是一种合成的降脂剂，是一种高效，耐受性好，口服活性的 HMG-CoA 还原酶抑制剂，Ki 为 1.3 nM/L。Cerivastatin sodium 可降低低密度脂蛋白胆固醇水平。Cerivastatin sodium 还主要通过 RhoA 抑制作用来抑制 MDA-MB-231 细胞的增殖和侵袭，具有抗癌作用。

Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.

Cell Proliferation Assay Cell Line:MDA-MB-231 cells Concentration:5 ng/mL, 10 ng/mL, 25 ng/mL, 50 ng/mL Incubation Time:3 days Result:Induced a dose-dependent decrease in cell proliferation of MDA-MB-231 cells.Cell Cycle Analysis Cell Line:MDA-MB-231 cells Concentration:25 ng/mL Incubation Time:18 hours, 36 hours Result:Induced a cell cycle block in G 1/S phase.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:25 ng/mL Incubation Time:18 hours Result:Induced a marked increase in the level of p21Waf1/Cip1.RT-PCRCell Line: MDA-MB-231 cells Concentration:25 ng/mL Incubation Time:12 hours Result:Increased p21Waf1/Cip1 mRNA levels.

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Apoptosis

Ferroptosis

Ferroptosis | Opioid Receptor | HMG-CoA Reductase

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143201-11-0

481.53

C26H33FNNaO5

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 100 mg/mL (207.67 mM; 超声助溶 (<60°C)

[O-]C(C[C@H](O)C[C@H](O)/C=C/C1=C(C(C)C)N=C(C(C)C)C(COC)=C1C2=CC=C(C=C2)F)=O.[Na+]

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(-20℃)

With Ice Pack

≥ 2 years