R 125489 ( R125489 | Laninamivir )

产品货号. M13161 CAS No. 203120-17-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

R 125489
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Laninamivir (R 125489) 是一种有效的流感神经氨酸酶 (NA) 抑制剂，其对流感病毒 H12N5 NA (N5)，pH1N1 N1 NA (p09N1) 和 A/RI/5+/1957 H2N2 N2 (p57N2) 的 IC50 分别为 0.90 nM、1.83 nM 和 3.12 nM。
产品描述

R 125489 (Laninamivir) is a potent influenza neuraminidase (NA) inhibitor, inhibits the NA activities of various type A and B influenza viruses, including subtypes N1 to N9 and oseltamivir-resistant viruses.(In Vitro):Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution.Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir.
体外实验

Laninamivir (R 125489) inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution.Laninamivir (R 125489) is potent against p57N2, p09N1 and N5 with a similar binding mode to Zanamivir.
体内实验

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同义词

R125489 | Laninamivir
通路

Microbiology/Virology
靶点

Influenza Virus
受体

Influenza Virus
研究领域

——
适应症

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CAS Number

203120-17-6
分子量

346.34
分子式

C13H22N4O7
纯度

>98% (HPLC)
溶解度

In Vitro:?H2O : 5 mg/mL (14.44 mM)
SMILES

O=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@H](C[C@@H](OC)CO)O1)O
化学全称

(4S,5R,6R)-5-Acetamido-4-guanidino-6-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid

1. Yamashita M, et al. Antimicrob Agents Chemother. 2009 Jan;53(1):186-92. 2. Koyama K, et al. Antimicrob Agents Chemother. 2009 Nov;53(11):4845-51.

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