Laninamivir

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Laninamivir (CS-8958) 是流感神经氨酸酶 (NA) 抑制剂 R-125489 的前药。

Laninamivir (CS-8958) is a prodrug of the influenza neuraminidase (NA) inhibitor R-125489, shows long-acting anti-influenza virus activity.Influenza Approved(In Vitro):Laninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively.(In Vivo):Laninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model.

Laninamivir octanoate (CS-8958) shows inhibitory activity with an IC50 of 631-1170 nM, 39.2-221 nM and 128 nM to the H1N1 viruses strains, H3N2 viruses strains and H2N2 (A/Singapore/1/57) virus, respectively.

Laninamivir octanoate (CS-8958; 95 μg/kg; intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection) treatment shows significantly life-prolonging effect in infected model. Animal Model:Female BALB/c mice (5-6 weeks old) infected with influenza A virus A/PR/8/34 Dosage:0.2 μmol/kg (95 μg/kg) Administration:Intranasal administration; three dose; at 4 h before and 4 h and 17 h postinfection Result:Showed life-prolonging effect in infected model.

CS-8958

Microbiology/Virology

Influenza Virus

Influenza Virus

Infection

Influenza

203120-46-1

472.539

C21H36N4O8

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (211.63 mM)

O=C(C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@H]([C@H](OC)[C@H](O)COC(CCCCCCC)=O)O1)O

(4S,5R,6R)-5-acetamido-4-guanidino-6-[(1R,2R)-2-hydroxy-1-methoxy-3-(octanoyloxy)propyl]-5,6-dihydro-4H-pyran-2-carboxylic acid

(-20℃)

With Ice Pack

≥ 2 years