T-1105

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

T-1105是一种广谱抗病毒抑制剂，对多种RNA病毒具有良好的活性。

T-1105 is a broad-spectrum antiviral inhibitor that demonstrates good activity for various RNA viruses, including influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), FMDV, and ZIKV; inhibits ZIKV replication with EC50 of 35 uM in a virus yield reduction assay.

T-1105 has antiviral activity against various RNA viruses, including Zika virus (ZIKV), influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), and foot-and-mouth disease virus (FMDV). T-1105 has good anti-RNA virus activity with values EC50 of 17 μM and 24 μM for parainfluenza-3 virus and Punta Toro virus in MDCK cells.T-1105 is a potential inhibitor of Zika virus replication.T-1105 can inhibit the SFTSV replication with an value IC50 of 49 μM in Vero cells and is not affect cell viability in 0-3 μM. Cell Cytotoxicity Assay Cell Line:Vero cells Concentration:1-4 μM Incubation Time:72 h Result:Had potential antiviral activity against ZIKV strain SZ01 with an value EC50 of 97.5 μM in Vero cells.Cell Viability Assay Cell Line:Vero cells Concentration:0-3 μM Incubation Time:4 h Result:Did not affect cell viability in the test range (0-3 μM).

T-1105 (Oral, 200 mg/kg, twice daily for 6 days) effectively inhibits the virus replication in the infected pigs. Animal Model:Pigs Dosage:200 mg/kg Administration:Oral, 200 mg/kg, twice daily for 6 daysResult:Reduced Viremia and increased anti-FMD antibody titers, did not observe any clinical signs of FMD.

T1105

Microbiology/Virology

Influenza Virus

Influenza Virus

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55321-99-8

139.114

C5H5N3O2

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (179.71 mM)

O=C1C(C(N)=O)=NC=CN1

Pyrazinecarboxamide, 3,4-dihydro-3-oxo- (9CI)

(-20℃)

With Ice Pack

≥ 2 years