EHNA hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EHNA hydrochloride 是一个强有力的和选择性的环核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脱氨酶 (ADA) 的双重抑制剂。EHNA hydrochloride 浓度依耐性抑制 cGMP 刺激的 PDE2 的活性，IC50 值分别为 0.8 μM (人类) 和 2 μM (猪心肌)，但是对没有刺激的 PDE2 抑制力较小。EHNA hydrochloride 在调节多种药理反应中发挥作用，包括抗病毒、抗肿瘤和抗心律失常作用。

EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 μM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 μM (human), 2 μM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects.

EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.

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Microbiology/Virology

Influenza Virus

Adenosine deaminase | Influenza Virus | PDE

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58337-38-5

313.83

C14H24ClN5O

>98% (HPLC)

In Vitro:?H2O 中的溶解度 : 100 mg/mL (318.64 mM; 超声助溶) DMSO 中的溶解度 : 83.33 mg/mL (265.53 mM; 超声助溶 (<60°C)

[C@H](CCCCCC)([C@@H](C)O)N1C=2C(N=C1)=C(N)N=CN2.Cl

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(-20℃)

With Ice Pack

≥ 2 years