Imidazole ketone erastin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

咪唑酮erastin（IKE，铁死亡诱导剂IKE）是一种有效的、代谢稳定的xc-系统抑制剂和铁死亡诱导剂，可能适合体内应用。

Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications; potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM); exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.

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Ferroptosis inducer IKE | IKE

Apoptosis

Ferroptosis

Ferroptosis

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1801530-11-9

655.152

C35H35ClN6O5

>98% (HPLC)

DMSO : ≥ 125 mg/mL 190.80 mM

O=C1N(C2=CC(C(CN3C=NC=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=C1C=CC=C6

3-(5-(2-(1H-imidazol-1-yl)acetyl)-2-isopropoxyphenyl)-2-((4-(2-(4-chlorophenoxy)acetyl)piperazin-1-yl)methyl)quinazolin-4(3H)-one

(-20℃)

With Ice Pack

≥ 2 years