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PF-05089771 free base
CAS No. 1235403-62-9
PF-05089771 free base ( PF05089771 free base )
产品货号. M10943 CAS No. 1235403-62-9
PF-05089771 free base 是一种有效的亚型选择性 Nav1.7 抑制剂，IC50 为 11 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1454 | 有现货 |
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| 10MG | ￥1834 | 有现货 |
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| 25MG | ￥3041 | 有现货 |
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| 50MG | ￥4343 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1606 | 有现货 |
|
生物学信息
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产品名称PF-05089771 free base
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-05089771 free base 是一种有效的亚型选择性 Nav1.7 抑制剂，IC50 为 11 nM。
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产品描述PF-05089771 free base is a potent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, shows no activity against Nav 1.5 and >10-fold selectivity over other Nav isoforms; specifically interacts with the voltage-sensor domain (VSD4); blocks the majority of TTX-S current (75%) at 30 nM in human DRG neurons (IC50=8.4 nM); exhibits action potentials in spinal slice electrophysiology recordings, mouse and human DRG neurons, demonstrates in vivo efficacy mouse capsaicin-induced neurogenic flare model.
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体外实验PF-05089771 is determined to be more than 1000-fold selective over tetrodotoxin-resistant (TTX-R) Nav1.5 and Nav1.8 channels (IC50s >10 μM) and exhibited a range of selectivity over TTX-sensitive (TTX-S) channels (10-fold for Nav1.2 to 900-fold for Nav1.3 and Nav1.4).PF-05089771 (30 nM) blocks the majority of TTX-S current (75.5 ± 10.5%, n = 5, Fig 5D) whilst 100 nM resulted in complete block.
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体内实验——
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同义词PF05089771 free base
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通路Membrane Transporter/Ion Channel
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靶点Sodium Channel
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受体Sodium Channel
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研究领域Neurological Disease
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适应症Pain
化学信息
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CAS Number1235403-62-9
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分子量500.354
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分子式C18H12Cl2FN5O3S2
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 34 mg/mL
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SMILESC1=CC(=C(C=C1Cl)C2=C(NN=C2)N)OC3=CC(=C(C=C3Cl)S(=O)(=O)NC4=CSC=N4)F
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化学全称Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Benzamil (hydrochlor...
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Silperisone HCl
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5-Tridecanol
5-Tridecanol blocks ion flux in sodium channels.
