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Ethacizine hydrochloride

CAS No. 57530-40-2

Ethacizine hydrochloride ( —— )

产品货号. M32921 CAS No. 57530-40-2

Ethacizine hydrochloride (Ethacizin; NIK-244) 是一种抗心律不齐的化合物 (Class Ic antiarrhythmic agent),比 Flecainidex 作用时间更持久。Ethacizine hydrochloride (Ethacizin; NIK-244) 可以抑制负责心房和 His-Purkinje 心室传导的电流的去极化。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Ethacizine hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Ethacizine hydrochloride (Ethacizin; NIK-244) 是一种抗心律不齐的化合物 (Class Ic antiarrhythmic agent),比 Flecainidex 作用时间更持久。Ethacizine hydrochloride (Ethacizin; NIK-244) 可以抑制负责心房和 His-Purkinje 心室传导的电流的去极化。
  • 产品描述
    Ethacizine hydrochloride (Ethacizin; NIK-244) is a longer-lasting Class Ic antiarrhythmic agent than?Flecainide. Ethacizine hydrochloride (Ethacizin; NIK-244) inhibits the depolarizing current responsible for the intraatrial and His-Purkinje-ventricular conduction.
  • 体外实验
    ——
  • 体内实验
    NIK-244 (1-300 ug) injects directly into the SA node and PM preparations shows negative chronotropic, negative inotropic and coronary vasodilator.
  • 同义词
    ——
  • 通路
    Membrane Transporter/Ion Channel
  • 靶点
    Sodium Channel
  • 受体
    Sodium Channel
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    57530-40-2
  • 分子量
    449.99
  • 分子式
    C22H28ClN3O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO 中的溶解度 : 100 mg/mL (222.23 mM; 超声助溶 )
  • SMILES
    Cl.CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN(CC)CC)c2c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Sugiyama A, et al. Comparison of cardiovascular effects of a novel class Ic antiarrhythmic agent, NIK-244, with those of flecainide in isolated canine heart preparations cross-circulated with a donor dog.Jpn J Pharmacol. 1991 May;56(1):1-12.?
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