Acecainide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-乙酰普鲁卡因酰胺是普鲁卡因酰胺的N-乙酰化代谢物，它是III类抗心律失常化合物，而普鲁卡因酰胺是Ia类抗心律失常化合物。

N-Acetylprocainamide is the N-acetylated metabolite of Procainamide, it is a Class III antiarrhythmic agent, whereas procainamide is a Class Ia antiarrhythmic drug.(In Vitro):N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion.

N-Acetylprocainamide is a K+ blocker. N-Acetylprocainamide decreases the tensions induced by K+ and methacholine. The pIC50 values for N-acetylprocainamide against the contractions induced by 0.3 and 1 μM methacholine are 2.80 ± 0.03 and 2.65 ± 0.02, respectively. And such a relaxant effect of N-Acetylprocainamide is inhibited by K+ channel blockers. N-Acetylprocainamide shows no effect on Na+ absorption or Cl- secretion.

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Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Other Indications

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32795-44-1

277.36

C15H23N3O2

>98% (HPLC)

Soluble in DMSO

CCN(CC)CCNC(=O)C1=CC=C(NC(C)=O)C=C1

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(-20℃)

With Ice Pack

≥ 2 years