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Lotamilast
CAS No. 947620-48-6
Lotamilast ( RVT 501;E6005 )
产品货号. M16789 CAS No. 947620-48-6
Lotamilast (RVT 501, E6005) is apotent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥551 | 有现货 |
|
| 5MG | ￥867 | 有现货 |
|
| 10MG | ￥1312 | 有现货 |
|
| 25MG | ￥2406 | 有现货 |
|
| 50MG | ￥4228 | 有现货 |
|
| 100MG | ￥6124 | 有现货 |
|
| 500MG | ￥12798 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Lotamilast
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lotamilast (RVT 501, E6005) is apotent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM.
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产品描述Lotamilast (RVT 501, E6005) is apotent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM; produces an immediate antipruritic effect as well as an anti-inflammatory effect with reduced expression of cytokines/adhesion molecules in mice after topical application; ameliorates the appearance of atopic dermatitis-like skin lesions in AD models.Dermatitis Phase 2 Clinical
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同义词RVT 501;E6005
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通路Angiogenesis
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靶点PDE
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受体PDE4;PDE-4
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研究领域Inflammation/Immunology
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适应症Dermatitis
化学信息
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CAS Number947620-48-6
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分子量472.50
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分子式C26H24N4O5
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纯度>98% (HPLC)
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溶解度（ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(OC)C1=CC=C(C(NC2=CC=CC(C3=C4C=C(OC)C(OC)=CC4=NC(NC)=N3)=C2)=O)C=C1
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化学全称methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ishii N, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):105-12.
2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.
3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.
4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.
2. Andoh T, et al. Exp Dermatol. 2014 May;23(5):359-61.
3. Kubota S, et al. Eur J Pharmacol. 2015 Dec 5;768:41-8.
4. Furue M, et al. Expert Opin Investig Drugs. 2017 Dec;26(12):1403-1408.
产品手册
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