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Cilomilast
CAS No. 153259-65-5
Cilomilast ( SB-207499;SB207499;SB 207499 )
产品货号. M12158 CAS No. 153259-65-5
A potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥365 | 有现货 |
|
| 5MG | ￥664 | 有现货 |
|
| 10MG | ￥1199 | 有现货 |
|
| 25MG | ￥2171 | 有现货 |
|
| 50MG | ￥3864 | 有现货 |
|
| 100MG | ￥5654 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Cilomilast
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.
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产品描述A potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4; shows selectivity for PDE4 over the other PDE isozymes and is 75-fold more selective than (R)-rolipram with respect to LPDE4 activity versus HPDE4 activity; inhibits antigen-induced bronchoconstriction in conscious guinea pigs at 30 mg/kg and orally acitive.COPD Phase 3 Discontinued
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同义词SB-207499;SB207499;SB 207499
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通路Angiogenesis
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靶点PDE
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受体HPDE4;LPDE4
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研究领域Inflammation/Immunology
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适应症COPD
化学信息
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CAS Number153259-65-5
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分子量343.42
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分子式C20H25NO4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C([C@H]1CC[C@](C2=CC=C(OC)C(OC3CCCC3)=C2)(C#N)CC1)O
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化学全称Cyclohexanecarboxylic acid, 4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, cis-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Christensen SB, et al. J Med Chem. 1998 Mar 12;41(6):821-35.
2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
2. Barnette MS, et al. J Pharmacol Exp Ther. 1998 Jan;284(1):420-6.
3. Griswold DE, et al. J Pharmacol Exp Ther. 1998 Nov;287(2):705-11.
产品手册
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