LR-90 ( —— )

产品货号. M26283 CAS No. 245075-84-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

LR-90
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.?
产品描述

LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.?(In Vitro):LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.?LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.(In Vivo):LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
同义词

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通路

Others
靶点

Other Targets
受体

BRD4
研究领域

——
适应症

——

CAS Number

245075-84-7
分子量

709.6
分子式

C35H34Cl2N4O8
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C)(Oc1ccc(NC(=O)Nc2ccc(Cc3ccc(NC(=O)Nc4ccc(OC(C)(C)C(O)=O)cc4)c(Cl)c3)cc2Cl)cc1)C(O)=O
化学全称

——

1.Susanta Samajdar, et al. Bicyclic heterocyclic derivatives as bromodomain inhibitors. WO2015104653A1

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